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Innovagen Nabolin (Dbol)

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  • Innovagen Nabolin (Dbol)
  • Innovagen Nabolin (Dbol)
  • Innovagen Nabolin (Dbol)

Dianabol 10mg - Nabolin by Innovagen

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Availability: In stock

$40.00

Manufacturer: Innovagen


Substance: Methandrostenolone


Pack: 10mg/50tablets

Details

Innovagen Nabolin aka Dbol (Methandrostenolone) is an anabolic, modified testosterone. It has some differences: 1) the methyl group in 17alpha position is added that makes possible to protect the drug while taking it orally, 2) a double bond between carbons 1 and 2 is inserted, and it shifts the anabolic and androgenic ratio toward the first (17a-methyl-17b-hydroxy-1,4-androstadiene-3-on).

Such a steroid possesses lower ability to bind to the androgen receptors, but at the same time it has a much longer half-life in comparison with testosterone, and lower ability to bind to the connecting proteins of blood. Due to these features methandrostenolone is a very potent anabolic steroid, although its ability to bind to receptors is weaker. Based on the results of recent research, its main mechanism of action involves interaction with the cell androgen receptors.

Historical Background

First records about methandrostenolone appeared in 1955. Ciba company manufactured and released the drug on the U.S. market in 1958, and back at that time it was called Dianabol. John Ziegler, a doctor of many U.S. Olympic teams promoted methandrostenolone for Ciba company.

The doctor paid his attention during competition on testosterone abuse in the athletes of the Soviet Union, Ziegler believed that this hormone had bad side effects. One of the athletes had a very strong increase in prostate, so he needed catheter for urine (due to the fact that testosterone is converted to dihydrotestosterone, and it affects the prostate tissue).

To avoid this, it is better to take a specific inhibitor of 5-alpha-reductase type II - finasteride. In the case when testosterone is used, it is quite successful solution if there are problems with the prostate. Ziegler and Ciba company checked created methandrostenolone on androgeny. Athletes who have worked with Ziegler achieved great results by taking methandrostenolone. At the beginning of 1960s it began to be actively used.

Since 1965, FDA became interested in Dianabol, and asked Ciba company to make a description of the possible medical use of Dianabol. Company agreed and made it at the same time including such points as treatment of the weakened and damaged bones in patients. In 1970, the FDA recognized that Dianabol could be useful in the treatment of post-menopausal osteoporosis and pituitary dwarfism.

All changes were reflected in the recommendations of the drug’s prescription in 1970, the Ciba company got permission to proceed with the sale and the research of the drug. As a result, the company had lost patent protection for the drug. Some companies, such as Bolar, Rugby release their own versions of drugs – generics on the market.

Pharmacological effect

Anabolic steroid. While penetrating into the nucleus it activates the genetic apparatus of the cell that leads to an increase in the synthesis of DNA, RNA and structural proteins, activation  of enzyme chain of tissue respiration and its increase, the oxidative phosphorylation, ATP synthesis and accumulation of macroergs in the cell. Stimulates the anabolic, thus inhibits catabolic processes caused by corticosteroids. Leads to an increase in muscle mass and decrease of fat deposits, and of negative nitrogen balance.

Hematopoietic effect is related to an increase in the synthesis of erythropoietin. Due to increased concentration of the inhibitor C-1 and the complement fraction and to reduce in content C-2 and C-4 of complement fractions anti-allergic effect is exerted. The presence of androgen activity may contribute to the development of male secondary sexual characteristics.

Methandrostenolone’s effects

• Promotes the rapid increase in muscle mass

• Accelerates protein synthesis

• Increases strength

• Improves appetite

• Strengthens the skeletal system

• Has anti-catabolic effect

Methandrostenolone Use

As a result of the research, it became known that the use of oral AAS along with a meal reduces the bioavailability of the drug. It happens due to the fact that AAS have liposoluble nature and some parts of the drug may dissolve in the food fat and this will reduce the absorption of AAS in the gastrointestinal tract. For maximum effect, the drug should be taken on an empty stomach.

Use (for men):

Dbol recommended dosage for men is 20-50mg daily. Although some users take as little as 20mg and up to100mg daily. While exceeding normal doses, the result is improved, but the number of adverse effects also increases. Innovagen Nabolin use should not exceed 6 weeks. Methandrostenolone may be used in combination with various drugs. It makes a good combination with a moderate anabolic nandrolone, such combinations gives great results. It also may be combined with testosterone esters for lean mass growth, but you should remember about androgenic side effects (as well as about aromatase inhibitors). Half-life of methandrostenolone is 3-5 hours. Taking the drug once a day will lead to increase and decrease of the drug level in the blood throughout the day. Sometimes it is recommended to use it several times a day, to maintain a constant level (preferably 4 times, once every 5 hours).

Use (for women):

Methandrostenolone is popular among men while in women it causes virilization. Sometimes, females carry out experiments using the drug in doses of 2.5-5mg per day. According to studies, androgenic side effects occur in women at a dosage of 10 mg per day, and in children starting from 2.5 mg per day.

Side effects

Methandrostenolone is aromatased, it has moderate estrogenic activity. Gynecomastia occurs not often, but can appear during the intake of high doses. In order to avoid it you should remember about tamoxifen.

Moreover, you may experience water retention. You can alternate dbol  intake with the use of an aromatase inhibitor, such as anastrozolol, however it can exert negative effects on blood lipids. It should be mentioned that methandrostenolone is structurally identical to boldenone, except the fact that it has no c17 boldenone-alpha methyl group.

Due to this difference it is clear why such similar substances have various effects on the body. In this case the key factor is the estrogenic side effects. Boldenone is usually used without any anti-estrogens. While methandrostenolone has more estrogens. Despite this, methandrostenolone does not aromatase faster. In fact, the c17-alpha and 1-2 double connections significantly inhibit the aromatization process. This happens because methandrostenolone is converted into 17-alfametilestradiol, more biologically active form of estrogen than estradiol.

Methandrostenolone is classified as an anabolic, but the risk of androgenic side effects is pretty high. Among them are: increased oiliness of the skin, acne, hair growth on the body and face. High doses may cause such side effects. Anabolic steroids can lead to deterioration of hair loss of male type. People, who are sensitive to the androgenic effects of methandrostenolone, should take another drug, such as boldenone.

Women should not forget about virilizing possible effects of AAS such as deepening of the voice, irregular periods, problems with skin texture, facial hair growth, and clitoral enlargement. Methandrostenolone undergoes the reaction with a 5a-reductase inhibitor and is converted to the more potent androgen - digidrometandrostenolon, but its quantity is small and androgenicity of methandrostenolone cannot significantly be altered with the parallel use of finasteride or dutasteride.

Methandrostenolone – is a 17-alpha alkylated drug. This modification protects the drug from deactivation by the liver, allowing a large percentage of the drug to get into the blood stream after oral administration. Alkylated AAS can be hepatotoxic. With long course of administration or at high doses it can lead to liver damage. Sometimes it is recommended to ask a doctor to monitor liver function during the cycle. Usage of alkylated AAS is typically limited to 4-6 weeks, in order to avoid increasing stress on the liver (during this period nothing bad will happen to liver).

As a result of the studies it was found that several weeks of methandrostenolone use at doses less than 10 mg causes minimal damage to liver. At a dose of 15 mg per day, most patients begin to fell abnormal liver function in the form of bromosulfalein retention. Even doses of 2.5 and 5 mg caused retention of this marker in the body.

Serious liver problems are rare in people who use AAS, however, they may appear, especially when taking high doses or it have been used during long periods of time. It is recommended to use ursosan (this is hepatoprotective and choleretic simultaneously) during the course. Intake of severe hepatoprotectors (for example, CARSIL) during the cycle can cause bile stasis and pain in the right side.

Contraindications for medical use

Hypersensitivity, prostate cancer, breast cancer (in men), breast cancer (in women with hypercalcemia), hypercalcemia, severe liver failure, nephrosis, glomerulonephritis (nephrotic stage) pregnancy. With caution, heart failure, coronary atherosclerosis, myocardial infarction, diabetes, prostatic hyperplasia, hepatic failure, renal failure, lactation (there is no data about the penetration of the drug in breast milk), old age. Childhood and adolescence (risk of premature closure of the epiphyseal growth zones, early puberty in boys and virilization in girls). Acceleration of the epiphyseal growth of tubular bones may occur in children both during treatment and last after its cancellation for six months.

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