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Sorry - Restal - Doxylamine Sleep Aid by Innovagen is no longer available.

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Innovagen Restal Doxylamine

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  • Innovagen Restal Doxylamine
  • Innovagen Restal Doxylamine
  • Innovagen Restal Doxylamine

Restal - Doxylamine Sleep Aid by Innovagen

Manufacturer: Innovagen

Substance: Doxylamine Succinate

Pack: 25mg/60tabs


Innovagen Restal has in its structure such a compound as doxylamine succinate and is available if form of 25mg pills.

Doxylamine succinate is an antihistaminic drug that aims at elimination of symptoms as, for example, sneezing, a cold in the head and lacrimation that are signs of hay fever, allergy, and chills. The principle of action lies in blocking of acetylcholine and histamine that are genuine compounds produced by the organism. Due to the fact that the drug exerts relaxing effect, it is also taken in order to treat occasional insomnia or wakefulness. That is why Innovagen Restal refers to the company's group of products under the name of Sleep Aides and Stress Reduction.

Intake and Doses

Innovagen Restal is available in form of tablets taken orally. If you suffer indigestion, you may use a drug with milk or food instead of water. Doxylamine succinate is absorbed through the digestive tract. The highest level of drug concentration of 100mg/mL in the plasma reaches within 2 - 3 hours after intake of 25 mg. The peak falls within 24 hours of dose to 28ng/ML or 10ng/mL within 36 hours of the dose.


Doxylamine is rapidly and almost completely absorbed after oral administration. In Cmaxv serum detected within 2-2.4 hours after administration at a dose of 25 mg and 99 ng / ml.

Doxylamine is metabolized primarily in the liver. The major metabolites are N-desmethyl doxylamine, N, N-didesmetil doxylamine and their N-acetyl-conjugates. It penetrates through the blood-tissue barriers, including GEB. T1 / 2 is in the range from 10.1 to 12 hours. The main part of the dose (approximately 60%) is excreted in unchanged form with the urine, partly - through the intestines.

Possible Side Effects of Doxylamine Succinate

Nowadays almost all the drugs cause side effects and before taking them it is better to get information about such effects. Doxylamine succinate refers to anticholinergic drugs and thus causes adverse effects related to such a group of medications.

Among them are dry mouth, urine retention, sleepiness, memory disorders, concentration problems, delusions, psychosis, and a strong sensibility to external irritants. It is should be noted that this drug cannot be combined with other medications such as Zyrtec (cetirizine) or Benadryl (diphenhydramine), since such a blend may raise the risk of severe adverse effects.

It is not advised to take doxylamine during a long period of time. Although, Doxylamine succinate does not cause addiction, and withdrawal effects are unlikely to be exerted after long courses.

Pregnant and Lactating Females

Pregnant or lactating females should not take Innovagen Restal, since it may exert negative effects on fetuses or nursing babies. It is recommended to ask the physician to choose the correct option.

• hypersensitivity to doxylamine or any other components of the drug 
• angle-closure glaucoma 
• prostatic hyperplasia, urinary retention 
• lactating period 
• children and teenagers under 15 years 
• hypersensitivity to the drug

Special instructions 
It is recommended to avoid activities that require rapid mental and motor responses. It should not be used by vehicles drivers during work and by people which profession related with high concentration of attention. Be careful during nighttime awakenings while taking the drug (possible confusion or dizziness). At the time of treatment alcohol intake is prohibited. 

Increases (mutually) deprimeiring influence of barbiturates, benzodiazepines, clonidine, opioid analgesics, neuroleptics, ethanol, and others. M-Anticholinergics increase the risk of anticholinergic side effects (dry mouth, urinary retention). Alcohol increases the sedative effect of doxilamine. 


Symptoms: daytime drowsiness, mydriasis, paresis of accommodation, dry mouth, redness of the face and neck, fever, sinus tachycardia, delirium, hallucinations, depressed mood, increased anxiety, coordination disorders, tremors, involuntary movements, convulsions, coma.

Customer Reviews

Good stuff Review by D-Cutter
Restal works great. Quick onset, strong and keeps going 7-8 hours. A Good alternative to benzos. Will buy again. (Posted on 2016-05-07)

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